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. 2021 Oct 21;2(4):319–331. doi: 10.1016/j.bpsgos.2021.10.002

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Transcriptional correlates of brain changes in neuropsychiatric disorders. (A) Gene expression profiles are associated with morphometric similarity differences between psychosis cases and controls. Cortical maps represent regional PLS1 scores (right) and case-control differences in morphometric similarity. (B) Associations between the cortical gene expression of SST interneurons, CORT, and NPY and reduced GBC in depression. The scatter plot represents the relationship for SST genes; regression lines represent relationships for all 3 gene markers. Panel (A) adapted with permission from (102). Panel (B) adapted with permission from (105). CORT, cortistatin; GBC, global brain connectivity; NPY, neuropeptide Y; PC1, first principal component; PLS, partial least squares; SST, somatostatin.