Table 3.
Longitudinal association between OH and progression of white matter hyperintensities, stratified by location.
| Total WMH | p value | DWMH | p value | PWMH | p value | MD white matter | p value | |
|---|---|---|---|---|---|---|---|---|
| Baseline age (years) | 0.458 (0.346–0.571) |
<0.001 | 0.128 (0.074–0.183) |
<0.001 | 0.330 (0.259–0.400) |
<0.001 | 0.002 (0.002–0.003) |
<0.001 |
| Sex (male) |
−0.078 (−1.662–1.506) |
0.99 | −0.240 (−1.155–0.675) |
0.75 | 0.433 (−0.712–1.578) |
0.69 |
−0.003 (−0.010–0.003) |
0.69 |
| Hypertension | 1.479 (−0.725–3.684) |
0.60 | 0.320 (−0.968–1.608) |
0.82 | 0.739 (−0.864–2.341) |
0.80 |
0.006 (−0.003–0.014) |
0.60 |
| OH | 3.633 (0.289–6.978) |
0.98 | 1.368 (−0.237–2.973) |
0.98 | 2.290 (0.211–4.369) |
0.98 | 0.018 (0.006–0.029) |
0.98 |
| FUP-time*age | 0.041 (0.031–0.051) |
<0.001 | 0.002 (−0.003–0.006) |
0.46 | 0.027 (0.018–0.036) |
<0.001 | 5.172e05 (−2.604e05–1.4e04) |
0.26 |
| FUP-time*OH | −0.061 (−0.375–0.256) |
0.97 | −0.035 (−0.172–0.101) |
0.97 | −0.101 (−0.374–0.174) |
0.97 | −0.001 (−0.004–0.002) |
0.97 |
| FUP-time*∆SBP | 0.002 (−0.005–0.008) |
0.66 | 0.001 (−0.002–0.004) |
0.66 | −0.002 (−0.007–0.004) |
0.58 | 1.181e05 (−4.077e5–6.440e05) |
0.66 |
| FUP-time*∆DBP | 0.004 (−0.009–0.017) |
0.97 | −0.001 (−0.005–0.005) |
0.97 | 0.002 (−0.009–0.012) |
0.97 | 8.554e06 (−9.255e05–1.095e4) |
0.97 |
Fixed effects results from linear mixed-effects models explaining progression of total WMH, DWMH, PWMH and MD. Data represents β-estimates (95% CI) or p-values. We studied the interaction between FUP time and OH and postural SBP/DBP changes, in the different models. In all models a quadratic term was included. WMH: white matter hyperintensities; DWMH: deep white matter hyperintensities; PWMH: periventricular white matter hyperintensities; MD: Mean Diffusivity; FUP: Follow-Up; OH: Orthostatic Hypotension; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure.