Table 4.
Longitudinal association between OH and change of cognitive index, executive function and psychomotor speed.
| Cognitive index | p value | Executive function | p value | Psychomotor speed | p value | |
|---|---|---|---|---|---|---|
| Baseline age (years) | −0.040 (−0.047–0.034) |
<0.001 | −0.037 (−0.043- −0.030) |
<0.001 | −0.043 (−0.051- −0.036) |
<0.001 |
|
Sex (male) |
−0.037 (−0.144–0.069) |
0.69 |
0.047 (−0.068–0.161) |
0.69 |
−0.077 (−0.201–0.046) |
0.69 |
| Hypertension | 0.004 (−0.145–0.152) |
0.99 | −0.050 (−0.145–0.152) |
0.82 | −0.017 (−0.190–0.156) |
0.95 |
| OH | −0.074 (−0.264–0.117) |
0.98 | −0.041 (−0.207–0.108) |
0.98 | −0.054 (−0.281–0.173) |
0.98 |
| FUP-time*age | −0.003 (−0.004—0.002) |
<0.001 | −0.003 (−0.003 - −0.002) |
<0.001 | −0.002 (−0.003- −0.002) |
<0.001 |
| FUP-time*OH | 0.022 (0.002–0.041) |
0.47 | 0.005 (−0.019–0.029) |
0.97 | 0.030 (0.004–0.055) |
0.47 |
| FUP-time*∆SBP | 3.23e04 (−7.798e05–7.219e04) |
0.58 | 3.68e06 (−4.757e4–4.818e04) |
0.66 | 3.987e04 (−1.136e04– 9.10e04) |
0.58 |
| FUP-time*∆DBP | 5.840e04 (−1.771e04–0.001) |
0.97 | −4.322e04 (−9.578e04–8.680e04) |
0.97 | 8.859e04 (−8.787e05–0.002 |
0.97 |
Fixed effects results from linear mixed-effects models explaining change of cognitive index, executive function and psychomotor speed over time. Data represents β-estimates with (95% CI) or p-values. We studied the interaction between FUP time and OH and postural SBP/DBP changes, in the different models. In all models a quadratic term was included. WMH: white matter hyperintensities; DWMH: deep white matter hyperintensities; PWMH: periventricular white matter hyperintensities; MD: Mean Diffusivity; FUP: Follow-Up; OH: Orthostatic Hypotension; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure.