Table 1.
Demographic, vascular risk factors, and hippocampal atrophy rates for TIA/IS patients and healthy controls (SD, standard deviation).
| Characteristics | Patient Group | Healthy Volunteer Group | P | |
|---|---|---|---|---|
| Number of subjects, n | 77 | 41 | ||
| Age, years (mean ± SD) | 65.0 ± 12.4 | 75.0 ± 5.7 | <0.01 | |
| Gender, males (%) | 62 (80.5%) | 18 (43.9%) | <0.01 | |
| Hypertension, n (%) | 39 (50.7%) | 21 (51.2%) | 0.95 | |
| Diabetes, n (%) | 12 (15.6%) | 0 (0%) | 0.01 | |
| BMI (kg/m2) (mean ± SD) | 27.0 ± 4.0 | 26.0 ± 4.3 | 0.11 | |
| WMH*1000 (mm3, mean ± SD) | 10.7 ± 9.2 | 3.2 ± 1.9 | <0.01 | |
| Baseline volume of left hippocampus (mm3, mean ± SD) | 3205.4 ± 420.0 | 3144.8 ± 416.4 | 0.31 | |
| Baseline volume of right hippocampus (mm3, mean ± SD) | 3341.9 ± 460.5 | 3240.1 ± 414.2 | 0.18 | |
| Baseline volume of total hippocampus (mm3, mean ± SD) | 6547.2 ± 855.2 | 6384.9 ± 809.0 | 0.17 | |
| Total (mean ± SD) | Absolute Annual Volumetric change (mm3) | 158.4 ± 86.9 | 45.4 ± 54.9 | <0.01 |
| Relative change annually | 4.9% ± 2.7% | 1.4% ± 1.7% | <0.01 | |
| Left (mean ± SD) | Absolute Annual Volumetric change (mm3) | 78.2 ± 60.2 | 28.6 ± 31.5 | <0.01 |
| Relative change annually | 2.5% ± 1.8% | 0.9% ± 1.0% | <0.01 | |
| Right (mean ± SD) | Absolute Annual Volumetric change (mm3) | 80.2 ± 46.2 | 16.8 ± 32.5 | <0.01 |
| Relative change annually | 2.5% ± 1.5% | 0.5% ± 1.0% | <0.01 |