Table 2.
A linear mixed effects model comparing longitudinal change in total hippocampal volume (HV) between TIA/IS patients and ADNI healthy controls, adjusting for demographic characteristics and vascular risk factors.
| Left HV change (mm3) | Right HV change (mm3) | Total HV change (mm3) | ||||
|---|---|---|---|---|---|---|
| Effect | Estimate [95% CI] | p values | Estimate [95% CI] | p values | Estimate [95% CI] | p values |
| TIA/IS vs control | −17.9 [−194.9, 159.1] | 0.84 | 23.9 [−165.0, 212.8] | 0.80 | 6.2 [−343.8, 356.2] | 0.972 |
| Years from the first scan | −28.7 [−38.1, −19.2] | <0.01 | −16.8 [−26.5, −7.2] | <0.01 | −45.5 [−61.8, −29.2] | <0.001 |
| TIA * years from the first scan | −49.3 [−65.7, −33.0] | <0.01 | −62.5 [−76.6, −48.4] | <0.01 | −111.8 [−137.2, −86.5] | <0.001 |
| Age | −7.8 [−15.3, −0.3] | 0.04 | −7.3 [−15.4, 0.7] | 0.07 | −15.1 [−29.9, −0.3] | 0.047 |
| Female vs male | −179.8 [−329.0, −30.6] | 0.02 | −146.8 [−306.6, 13.0] | 0.07 | −326.2 [−622.4, −30.0] | 0.031 |
| WMH volume (mm3) | −12.7 [−21.6, - 3.7] | <0.01 | −12.6 [−22.2, −3.1] | 0.01 | −25.2 [−42.9, −7.5] | 0.005 |
| Brain volume (mm3) | 0.9 [−0.1, 1.9] | 0.19 | 1.2 [−0.1, 2.2] | 0.14 | 2.1 [0.1, 4.1] | 0.042 |
| BMI | 10.8 [−5.3, 26.9] | 0.19 | 16.8 [−0.5, 34.0] | 0.06 | 27.6 [−4.4, 59.6] | 0.091 |
| Hypertension (Yes vs no) | −87.6 [−218.3, 43.2] | 0.01 | −101.7 [−241.5, 38.1] | 0.15 | −189.1 [−448.3, 70.2] | 0.153 |