Figure 1.

Early-onset and typical-onset AN show significantly different genetic correlation patterns with risk and comorbid traits. FDR-significant differences in genetic correlations were detected in two categories—anthropometric and reproductive—within six previously identified categories of risk or comorbid traits of interest for AN. (A) Sixty-two phenotypes were tested; duplicate phenotypes are not plotted (for duplicate phenotypes, we prioritized published summary statistics or the r_g difference with the lowest SE). Full results are shown in Table S9 in Supplement 2. (B) Shows the r_gs between the phenotypes and the age of onset subphenotypes. The error bars in both plots represent the SE. ADHD, attention-deficit/hyperactivity disorder; AN, anorexia nervosa; BMI, body mass index; FDR, false discovery rate; HbA1C, hemoglobin A_1c; HDL, high-density lipoprotein; HOMA-B, homeostatic model assessment for beta cell function; HOMA-IR, HOMA for insulin resistance; LDL, low-density lipoprotein; PGC, Psychiatric Genomics Consortium; RGC, ReproGen Consortium; UKB, UK Biobank.