Table 4.
Difference in radiological measures in individuals with and without incipient dementia.
| Imaging variable | ß (95% CI) | p-value |
|---|---|---|
| WMH volume (mL) | 8.59 (4.62– 13.1) | <0.001 |
| CBF GM (mL/100gr/minute) | -3.04 (-14.25 – 8.17) | 0.60 |
| CBF GM crushed (mL/100gr/minute) | -0.05 (-10.51 – 10.41) | 0.99 |
| CBF spatial CoV (SD) a | 0.17 (-0.34 – 0.67) | 0.52 |
| CBF spatial CoV, crushed (SD) a | 0.12 (-0.37 - 0.62) | 0.64 |
Results of repeated measurements mixed models.
a
These variables were introduced on a log scale. All measures adjusted for age, antihypertension medication use, and sex. WMH additionally adjusted for TBV. Abbreviations: CI=confidence interval. GM = grey matter, WMH = white matter hyperintensity, CBF = cerebral blood flow, CoV = coefficient of variation, crushed = measure for cerebral microvasculature ∆ = scan 2-scan 1/number of years between scan 1 and scan 2.