Figure 4.

Physiological roles of S. aureus peptidoglycan hydrolases. Peptidoglycan hydrolases play different essential roles during bacterial growth and division. PGHs are involved in the entire cell cycle including cell enlargement (i), cell enlargement during septum formation (ii), daughter cell separation upon cell division (iii), and remodelling of the peptidoglycan network after daughter cell separation (iv). In addition, peptidoglycan hydrolases serve in peptidoglycan turnover (v) and they modulate cell wall passage of cell surface-located proteins (vi).