Table 2.
Peptidoglycan hydrolase regulation at the transcriptional level.
| Gene encoding PGHs | Main transcriptional regulators |
|---|---|
| sagA | - |
| sagB | - |
| atl | WalKR (↑) (Dubrac et al. 2007), SigB (↑) (Houston et al. 2011), AtlR (↓) (Houston et al. 2011), SarA (↓) (Trotonda et al. 2009), GraSR (↑) (Herbert et al. 2007, Falord et al. 2011) |
| aly/scaH | - |
| lytN | ArlRS (↓) (Memmi et al. 2012), MgrA (↓) (Luong et al. 2006), Rot (↓) (Chu et al. 2013), Rat (↓) (Ingavale et al. 2003) |
| lytH | - |
| ssaA | WalKR (↑) (Dubrac et al. 2007), GraSR (↑) (Falord et al. 2011), SaeSR (↓) (Rogasch et al. 2006), Agr (↓) (Dunman et al. 2001), putative RNAIII (↓) (Lioliou et al. 2016) |
| essH | GraSR (↑) (Falord et al. 2011) |
| sa2353 | WalKR (↑) (Dubrac et al. 2007), RNAIII (↓) (Boisset et al. 2007), GraSR (↑) (Falord et al. 2011) |
| sle1/aaa | WalKR (↑) (Delauné et al. 2012), Agr (↓) (Hirschhausen et al. 2012), SarA (↓) (Hirschhausen et al. 2012), GraSR (↑) (Herbert et al. 2007, Falord et al. 2011) |
| sa0710 | WalKR (↑) (Dubrac et al. 2007), ArlRS (↓) (Crosby et al. 2020), MgrA (↓) (Luong et al. 2006) |
| sa0620 | WalKR (↑) (Dubrac et al. 2007), GraSR (↑) (Falord et al. 2011) |
| sa2097 | WalKR (↑) (Dubrac et al. 2007), GraSR (↑) (Falord et al. 2011) |
| sa2332 | WalKR (↑) (Delauné et al. 2012), GraSR (↑) (Falord et al. 2011) |
| lytM | WalKR (↑) (Dubrac et al. 2007), Rot (↓) (Chu et al. 2013), Agr (↓) (Ramadurai et al. 1999), SarA (↓) (Ramadurai et al. 1999), RNA III (↓) (Chunhua et al. 2012), Rat (↓) (Ingavale et al. 2003) |
| lytU | VraSR (↑) (Pietiäinen et al. 2009) |
| isaA | WalKR (↑) (Dubrac et al. 2007, Stapleton et al. 2007), SarA (↑) (Stapleton et al. 2007), SrrAB (↑) (Stapleton et al. 2007), putative RNAIII (↓) (Lioliou et al. 2016), GraSR (↑) (Falord et al. 2011) |
| sceD | WalKR (↑) (Dubrac et al. 2007, Stapleton et al. 2007), SigB (↑) (Ziebandt et al. 2001, Stapleton et al. 2007), Agr (↑) (Stapleton et al. 2007), putative RNAIII (↓) (Lioliou et al. 2016), LytSR (↓) (Stapleton et al. 2007), SaeSR (↓) (Stapleton et al. 2007), GraSR (↑) (Falord et al. 2011), SarA (↓) (Stapleton et al. 2007) |
*
Genes for functionally uncharacterized PGHs are named by their S. aureus N315 accession codes; (↑) and (↓), up- or down-regulation of the respective PGH-encoding gene; -, unknown regulation mechanism.