TABLE 1.

List of significant metabolites in AC against YC.

Mode	Metabolite	ID	MW	RT	FC
+	2,4-Dihydroxybenzophenone	mzc604	214.0623	0.547	+1.19
+	Aspartylphenylalanine	HMDB0000706	280.1055	3.793	−12.88
+	Bis(4-ethylbenzylidene)sorbitol	mzc7437	414.2036	10.691	−1.26
+	Cytosine	HMDB0000630	111.0434	0.722	+1.40
+	Decanoylcarnitine	HMDB0000651	315.2402	8.324	+4.69
+	Ketamine	HMDB0015352	237.0916	4.973	−2.12
+	L-Palmitoylcarnitine	HMDB0000222	399.3341	11.574	+10.74
+	Methacholine	HMDB0015654	159.1257	0.874	−3.12
+	Nicotinamide adenine dinucleotide	HMDB0000902	663.108	1.151	−7.19
+	Pipecolic acid	HMDB0000070/HMDB0005960/HMDB0000716	129.079	0.821	−1.70
+	Spermine	HMDB0001256	202.2156	0.369	−2.26
+	Uric acid	HMDB0000289	168.0282	0.955	+2.97 (+2.90)
+	Xylazine	HMDB0259938	220.1031	5.268	−3.05
−	3-Phosphoglyceric acid	HMDB0000807	185.9922	0.524	−40.86
−	Citric acid	HMDB0000094	192.0262	0.911	+4.19
−	Glyceric acid	HMDB0000139	106.0256	0.596	−2.41
−	Glycerol 3-phosphate	HMDB0000126	172.0128	0.522	+7.30
−	Mannose 6-phosphate/Fructose 1-phosphate/Beta-D-Fructose 6-phosphate/Glucose 1-phosphate/	HMDB0001078/HMDB0001076/HMDB0003971/HMDB0001586/HMDB0001401	260.0295	0.517	−2.98
−	Phosphoenolpyruvic acid	HMDB0000263	167.9816	0.601	−18.07

YC, as denominator.

FC: positive mode (negative mode).

Potential metabolite identified by cross referencing with mzCloud data (^).

Symbol: (+) increase; (-) decrease.

Acronym: FC (fold change); m/w (molecular weight); RT (retention time).