FIG. 3.

(a)–(d) Shear stress profiles at the side of Disse space [(a) and (c)] or sinusoidal cavity [(b) and (d)] on endothelium under varied hepatic microvillus thicknesses [(a) and (b)] or endothelium thickness [(c) and (d)]. Red or black lines were added in a or c to visualize their trends explicitly. (e)–(j) Distribution of flow-induced shear stress along the intersection of endothelial branches, when the thickness of hepatic microvillus was set to be 0.0 (e), 0.4 (f), or 0.8 μm (g), or when the thickness of endothelium was set to be 0.5 (h), 1.0 (i), or 1.5 μm (j). (k) Shear stress profile at permeability coefficient of endothelial cells of 2.5 × 10⁻¹⁶ m².