FIG 4.

Polyclonality detected in genes associated with resistance. For each of these genes, the detection of multiple mutations in a single NSCLC biopsy is more common in LBx than in tissue biopsies collected at the primary/local site (first bar) and metastatic tissue biopsies (Met); (A) ALK in NSCLC, (B) AR in prostate, (C) BRCA2 in prostate, (D) ESR1 in breast, (E) RB1 in breast, (F) NF1 in breast, (G) BRCA2 in breast, (H) EGFR in CRC, and (I) KRAS in CRC. The number of each cohort is provided in parentheses. (A, C, G, and I) For driver alterations, samples with only one mutation were omitted from the plot. CRC, colorectal cancer; LBx, liquid biopsy; NSCLC, non–small-cell lung cancer.