REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD3	Abcam	SP7, ab16669; RRID: AB_443425
CD45	Biopharmingen	Clone 30-F11, #553076; RRID: AB_394606
EMB	In-house (Stephen L. Nutt), Pridans et al., 2008	G7.43.1
F4/80	BioLegend	BM8, #123115; RRID: AB_893493
FASN	Santa Cruz Biotechnology	G-11, sc48357; RRID: AB_627584
FN	Abcam	ab2413; RRID: AB_2262874
GATA6	Cell Signalling	D61 E4 clone, #5851; RRID: AB_10705521
GST (Delfia Eu-N1-anti-GST)	PerkinElmer	AD0251
ITGα6-FITC	eBioscience	GoH3 clone, 14-0495-82; RRID: AB_891480
K14	BioLegend	Poly19053; #905303; RRID: AB_2734678
Ki67	Abcam	SP6, ab16667; RRID: AB_302459
Laminin	Sigma	L9393; RRID: AB_477163
LRIG1	R&D Biosystems	#AF3688; RRID: AB_2138836
MCT1	Millipore	AB1286-1; RRID: AB_90565
PPARγ	Santa Cruz Biotechnology	E-8, sc7273; RRID: AB_628115
SCD1	Cell Signaling	C12H5, #2794; RRID: AB_2183099
SCD1	R&D Biosystems	Clone#428208, #MAB4404; RRID: AB_2183118
Bacterial and virus strains
BL21Tuner	Novagen (Sigma- Aldrich)	70622-M
BL21Tuner-pGex-2T-Embigin ecto	This paper	N/A
BL21Tuner-pGex-2T-Neuroplastin ecto	This paper	N/A
BL21Tuner-pGex-2T-Basigin ecto	This paper	N/A
BL21Tuner-pGex-2T-W1Embigin	This paper	N/A
BL21Tuner-pGex-2T-W2Embigin	This paper	N/A
Chemicals, peptides, and recombinant proteins
Fibronectin N-terminal heparin binding fragment	Sigma-Aldrich	F9911
Fibronectin 45kDa gelatin binding fragment	Sigma-Aldrich	F0162
Recombinant Human Fibronectin Fragment 2 (Ser607-Pro1265),	R&D Systems	#3225-FN
Recombinant Human Fibronectin Fragment 3 (Glu1266-Pro1908)	R&D Systems	#3938-FN
Recombinant Human Fibronectin Fragment 4 (Val1913-Glu2477)	R&D Systems	#3624-FN
Corning™ Fibronectin, Human	Thermo Fisher Scientific	11533610
Recombinant Human Integrin alpha5beta1	R&D Systems	#3230-A5-050
ProLong Gold Antifade Mountant	ThermoFisher, Canoga Park, California	ref: P36930
5-Ethynyl-2′-deoxyuridine	Sigma	900584
Critical commercial assays
Protino Glutathione Agarose 4B	Macherey-Nagel Germany	REF 745500.100
RNAscope Multiplex Fluorescent Detection Kit v2	ACDBio, Newark, California	ref: 323100
RNAscope Slc16a1 (mouse)	ACDBio, Newark, California	ref: 423661-C2
RNAscope Bsg (mouse)	ACDBio, Newark, California	ref: 491721)
Opal 570 Reagent Pack dye	Akoya Biosciences, Marlborough, Massachusetts	ref: FP1488001KT
L-lactate assay kit	Abcam	ab65330
Duolink In Situ Wash Buffers, Fluorescence	Sigma	DUO82049
Duolink In Situ Mounting Medium with DAPI	Sigma	DUO82040
Duolink In Situ Probemaker PLUS	Sigma	DUO92009-1KT
Duolink In Situ Probemaker MINUS	Sigma	DUO92010-1KT
Duolink In Situ Detection Reagents Red	Sigma	DUO92008-30RXN
Silica gel on TLC plates, L × W 20 cm × 20 cm, fluorescent indicator: no,	Merck	99570-25EA
Methyl cis-15-tetracosenoate	Merck	17265
Click-iT™ EdU Imaging Kit with Alexa Fluor™ 488	Invitrogen	C10337
Deposited data
Analysis of published mouse skin scRNA-seq data	Joost et al., 2016	GEO: GSE67602
Analysis of published human skin scRNA-seq data	Cheng et al., 2018	EGA: EGAS00001002927
Basigin crystal structure	Wright et al., 2014	PDB: 4U0Q
Basigin crystal structure	Yu et al., 2008	PDB: 3BH5
Neuroplastin crystal structure	Owczarek et al., 2010	PDB: 2WV3
Neuroplastin crystal structure	Gong et al., 2018	PDB: 6A69
Experimental models: cell lines
Mouse skin keratinocytes	In-house, Ghahramani et al. 2018	N/A
Experimental models: organisms/strains
Mouse: K14ΔNLef1	In-house, Nieman et al., 2002	N/A
Mouse: K14ΔNβ-CateninER (D2 line)	In-house, Lo Celso et al., 2004	N/A
Mouse: TopH2BeGFP	Ferrer-Vaquer et al., 2010	N/A
Mouse: TUKO53 Emb-/-	In-house, Silberstein et al., 2016	N/A
Mouse: K14Cre	Dassule et al., 2000	N/A
Mouse Emb flox/flox	Talvi et al., 2021	N/A
Oligonucleotides
Mm_Emb_1 Flexitube siRNA	QIAGEN	Cat#SI00993307
Mm_Emb_4 Flexitube siRNA	QIAGEN	Cat#SI00993328
AllStars Negative Control siRNA	QIAGEN	Cat#1027280
RNAscope mouse Bsg	ACDBio	ref: 491721
RNAscope mouse Slc16a1	ACDBio	ref: 423661-C2
Recombinant DNA
CCSB-Broad LentiORF - EMB Clone Accession: BC059398 Clone ID: ccsbBroad304_04883 glycerol stock	Horizon Discovery Ltd (Dharmacon)	OHS6085-213577454
PLX304	Adgene	#25890
pcDNA3.1+-EMB	This paper	N/A
pGex-2T-Embigin ecto	This paper	N/A
pGex-2T-Neuroplastin ecto	This paper	N/A
pGex-2T-Basigin ecto	This paper	N/A
pGex-2T-W1Embigin	This paper	N/A
pGex-2T-W2Embigin	This paper	N/A
Software and algorithms
Origin 2016	OriginLab Corporation	N/A
GraphPad Prism 6	GraphPad Software	RRID:SCR_00279
Harmony 4.8 High-Content Imaging and Analysis Software	PerkinElmer	HH17000001
Phasefocus Analyse V3.0.1 + Random Motility Dashboard	Phase Focus Limited	N/A
NDP.view2 (U12388-01)	Hamahatsu	N/A
Fiji – ImageJ	Schindelin et al., 2012	N/A