Table 2.

Performance of FDG-PET/CT for the diagnosis of FUO by study design, mandatory test, and imaging test in 26 clinical studies

No.	Author	Enrolled cases	Disease type causing FUO (%)					Reported or calculable results						Redefining
			Infection	NIID	Malignancy	Miscellaneous	Undiagnosed	Sensitivity	Specificity	PPV	Accuracy	DY	TP/FN/FP/TN	TP/FN/FP/TN
1	Keidar et al. [59]	48	19	33	6	2	40	100	81	81	90	46	22/0/5/21	22/7/4/15
2	Balink et al. [60]	68	37	21	3	4	35	100	90	93	96	56	38/6/3/21	38/6/3/21
3	Federici et al. [61]	14	29	36	7	0	29	70	75	88	71	50	7/3/1/3	7/3/1/3
4	Ferda et al. [62]	48	38	38	17	0	8	98	75	98	96	90	43/1/1/3	43/1/1/3
5	Kei et al. [63]	12	33	8	17	0	42	71	60	71	67	42	5/2/2/3	5/2/2/3
6	Sheng et al. [64]	48	31	19	25	0	25	89	33	80	75	67	32/4/8/4	32/4/8/4
7	Pelosi et al. [65]	24	25	29	13	4	29	65	71	85	67	46	11/11/2/0	11/6/1/6
8	Ergül et al. [66]	24	13	13	21	8	46	92	45	63	79	50	12/0/7/5	12/1/6/5
9	Kim et al. [67]	48	29	4	15	38	15	89	20	61	60	52	25/3/16/4	25/16/3/4
10	Crouzet et al. [68]	79	29	25	15	8	23	98	87	96	95	74	45/19/2/13	Unclassifiable
11	Pedersen et al. [69]	22	5	41	14	0	41	67	71	83	68	45	10/5/2/5	10/4/2/6
12	Nakayo et al. [70]	20	15	15	25	0	45	79	83	92	80	55	11/3/1/5	12/8/0/0
13	Manohar et al. [71]	103	30	21	13	3	33	90	97	98	92	60	62/7/1/3	62/7/1/3
14	Tokmak et al. [72]	25	32	40	12	0	16	94	80	94	90	71	15/1/1/4	15/6/1/3
15	Gafter-Gvili et al. [73]	112	44	15	13	2	26	72	58	75	65	46	52/20/17/23	51/32/9/20
16	Bucher-Olsen et al. [74]	57	51	21	7	7	14	93	60	68	75	44	25/2/12/18	25/24/3/5
17	Singh et al. [75]	47	19	21	11	2	47	82	32	51	55	38	18/4/17/8	18/7/14/8
18	Pereira et al. [76]	76	21	12	22	5	40	77	31	61	58	45	32/14/0/5	43/3/10/20
19	Hung et al. [77]	58	40	19	17	3	21	79	56	83	72	57	33/9/7/9	33/13/4/8
20	García-Vicente et al. [78]	67	31	49	6	1	12	84	31	62	61	48	32/6/20/9	32/26/0/9
21	Okuyucu et al. [79]	74	26	45	9	5	14	75	69	92	74	62	46/15/4/9	46/19/0/9
22	Georga et al. [80]	50	40	22	16	0	22	95	50	84	84	72	36/2/6/6	36/4/4/6
23	Das et al. [81]	43	23	37	9	5	26	77	33	83	51	47	20/6/4/2	20/12/11/0
24	Letertre et al. [82]	39	23	44	8	5	21	85	37	58	62	44	17/3/12/7	17/3/12/7
25	Buchritis et al. [83]	303	37	17	18	0	28	89	82	87	86	52	158/20/23/102	158/20/23/102
26	Mahajna et al. [84]	128	48	16	9	1	26	70	37	70	67	47	60/16/26/26	60/33/9/26

NIID noninfectious inflammatory disease, PPV positive predictive value, DY diagnostic yield, TP true positive, FN false negative, FP false positive, TN true negative