Table 3.

Performance of FDG-PET/CT for the diagnosis of FUO based on literature and redefining in 26 clinical studies

Index		Median					Result based on literature					Redefined
		Sensitivity	Specificity	PPV	Accuracy	DY	Sensitivity	Specificity	PPV	Accuracy	DY	Sensitivity	Specificity	PPV	Accuracy	DY
All 26 studies		84.5	60	83	73	50	83	64	81	76	54	75	71	86	74	53
Study design	Prospective	82	56	81	72	46	85	57	72	73	48	73	58	77	68	48
	Retrospective	85	60	83	74	50	82	64	82	76	55	76	73	87	75	54
Laboratory test before PET/CT	None	98	75	93	96	56	91	82	93	88	67	91	82	93	88	67
	BT	77	37	62	62	45	72	42	73	63	50	73	65	82	71	50
	BT and BC	92.5	59	82	81.5	51	84	71	83	85	56	77	75	86	83	56
	BT, BC, BT for NIID	80.5	53	85.5	72.5	53.5	72	65	86	70	54	83	55	79	74	55
Imaging test before PET/CT	None	80.5	65.5	77	67.5	46.5	82	62	85	77	60	80	78	90	80	58
	Chest X-ray and/or AUS	83	78.5	90	80	56	83	82	91	83	56	83	80	89	82	55
	CT	87	53	77.5	73.5	48.5	82	51	73	70	51	69	60	83	67	51

PPV positive predictive value, DY diagnostic yield, BT blood test, BC blood culture, NIID noninfectious inflammatory disease, AUS abdominal ultrasonography, CT computed tomography