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. 2022 Oct 28;12:18211. doi: 10.1038/s41598-022-22885-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Monoclonal wild-type cell line and corresponding subclones show similar transcriptomic profiles in contrast to the polyclonal wild-type. Volcano plots with differentially expressed genes in five different subclone cell lines of the parental monoclonal cell line in comparison with the parental monoclonal cell line (A–E). A bar chart (F) summarizes total amount of differentially expressed genes comparing parental cell line with polyclonal wild-type cell line as well as subclones with parental cell line. Threshold for false discovery rate (FDR) was set to log₁₀ ≥ 2. Threshold for fold change was set to log₂ ± 1. Grey dots represent genes which do not meet threshold criteria (FDR log₁₀ < 2 and/or log₂ (fold change) between ± 1).