Table 2.
Stepwise Cox regression analysis of associations of biomarkers with cardiovascular death and nonfatal AMI.
| Comparison | Sex | Model | eHR | 95% CI | Pr > ChiSq |
|---|---|---|---|---|---|
| Cardiovascular death | |||||
| Group 1 versus group 2 | Men | cTnI | 3.01 | 1.42–6.37 | 0.01 |
| CRP | 3.19 | 1.53–6.64 | 0.01 | ||
| Women | cTnI | 3.00 | 1.17–7.68 | 0.02 | |
| Men and women | PCSK9 | 0.52 | 0.29–0.96 | 0.04 | |
| Galectin-3 | 1.90 | 1.06–3.42 | 0.03 | ||
| cTnI | 2.81 | 1.56–5.05 | 0.01 | ||
| Group 1 versus group 5 | Men | ANGPTL3 | 0.14 | 0.03–0.62 | 0.01 |
| cTnI | 4.34 | 2.04–9.24 | 0.01 | ||
| CRP | 4.13 | 1.94–8.81 | 0.01 | ||
| Women | cTnI | 3.44 | 1.35–8.74 | 0.01 | |
| Men and women | ANGPTL3 | 0.23 | 0.07–0.76 | 0.02 | |
| cTnI | 3.35 | 1.87–6.00 | < 0.0001 | ||
| CRP | 1.97 | 1.11–3.48 | 0.02 | ||
| Group 1 versus group 6 | Men | Endothelin | 0.33 | 0.14–0.77 | 0.01 |
| Galectin-3 | 2.12 | 1.01–4.46 | 0.05 | ||
| ANGPTL3 | 0.10 | 0.02–0.42 | 0.01 | ||
| cTnI | 3.58 | 1.65–7.76 | 0.01 | ||
| CRP | 3.59 | 1.68–7.68 | 0.01 | ||
| Women | ANGPTL3 | 0.10 | 0.01–0.72 | 0.02 | |
| cTnI | 3.06 | 1.20–7.80 | 0.02 | ||
| Men and women | Endothelin | 0.48 | 0.23–0.97 | 0.04 | |
| ANGPTL3 | 0.13 | 0.04–0.42 | 0.00 | ||
| cTnI | 3.17 | 1.77–5.68 | < 0.0001 | ||
| CRP | 2.16 | 1.22–3.82 | 0.01 | ||
| Nonfatal AMI | |||||
| Group 3 versus group 4 | Men | PCSK9 | 2.03 | 1.06–3.91 | 0.03 |
| NOx | 2.08 | 1.08–4.00 | 0.03 | ||
| Women | NOx | 3.26 | 1.47–7.23 | 0.01 | |
| Insulin | 2.74 | 1.23–6.09 | 0.01 | ||
| Men and women | PCSK9 | 1.67 | 1.01–2.76 | 0.05 | |
| NOx | 2.60 | 1.57–4.31 | < 0.0001 | ||
| Group 3 versus group 5 | Men | ANGPTL3 | 2.91 | 1.49–5.68 | < 0.0001 |
| Women | Leptin | 0.24 | 0.09–0.66 | 0.01 | |
| cTnI | 3.47 | 1.40–8.64 | 0.01 | ||
| NOx | 4.10 | 1.81–9.31 | 0.01 | ||
| Insulin | 5.52 | 2.00–15.29 | 0.01 | ||
| Total cholesterol | 2.55 | 1.05–6.17 | 0.04 | ||
| Men and women | ANGPTL3 | 3.29 | 1.96–5.51 | < 0.0001 | |
| cTnI | 1.79 | 1.08–2.98 | 0.03 | ||
| NOx | 2.41 | 1.47–3.96 | 0.01 | ||
PCSK9, proprotein convertase subtilisin/kexin type; ANGPTL3, angiopoietin-like protein 3; NOx, nitrate and nitrite; cTnI, cardiac troponin I; CRP, C-reactive protein; eHR, estimated hazard ratio.