Table 3.
Summary of biomarkers included in stepwise Cox regression analysis for associations with cardiovascular death and nonfatal AMI in men and women.
| Total models | Mean eHR for all models | 95%CI (mean for all models) | Pr > ChiSq | Men, models | Women, models | Men and women, models | |
|---|---|---|---|---|---|---|---|
| Cardiovascular death | |||||||
| cTnI | 9 | 3.31 | 1.56–7.15 | 0.01 | 3 | 3 | 3 |
| ANGPTL3 | 5 | 0.14 | 0.04–0.59 | 0.01 | 2 | 1 | 2 |
| CRP | 5 | 3.01 | 1.49–6.09 | 0.01 | 3 | 0 | 2 |
| Endothelin | 2 | 0.40 | 0.19–0.87 | 0.03 | 1 | 0 | 1 |
| Galectin-3 | 2 | 2.01 | 1.03–3.94 | 0.04 | 1 | 0 | 1 |
| PCSK9 | 1 | 0.52 | 0.29–0.96 | 0.04 | 0 | 0 | 1 |
| Nonfatal AMI | |||||||
| NOx | 5 | 2.89 | 1.48–5.76 | 0.01 | 1 | 2 | 2 |
| ANGPTL3 | 2 | 3.10 | 1.73–5.60 | 0.00 | 1 | 0 | 1 |
| cTnI | 2 | 2.63 | 1.24–5.81 | 0.02 | 0 | 1 | 1 |
| Insulin | 2 | 4.13 | 1.61–10.69 | 0.01 | 0 | 2 | 0 |
| PCSK9 | 2 | 1.85 | 1.03–3.34 | 0.04 | 1 | 0 | 1 |
| Leptin | 1 | 0.24 | 0.09–0.66 | 0.01 | 0 | 1 | 0 |
| Total cholesterol | 1 | 2.55 | 1.05–6.17 | 0.04 | 0 | 0 | 1 |
PCSK9, proprotein convertase subtilisin/kexin type; ANGPTL3, angiopoietin-like protein 3; NOx, nitrate and nitrite; cTnI, cardiac troponin I; CRP, C-reactive protein; eHR, estimated hazard ratio.