Table 4.
Multivariate Cox regression analysis for associations of top 11 biomarkers with cardiovascular deaths and nonfatal AMI adjusted for sex and age.
| Comparison | Biomarker | eHR | 95% CI | Pr > ChiSq |
|---|---|---|---|---|
| Cardiovascular death | ||||
| Group 1 versus group 2 | cTnI | 2.59 | 1.20–5.60 | 0.02 |
| ANGPTL3 | 0.39 | 0.11–1.44 | 0.16 | |
| NOx | 1.36 | 0.72–2.57 | 0.34 | |
| CRP | 2.00 | 1.06–3.76 | 0.03 | |
| PCSK9 | 0.71 | 0.37–1.36 | 0.30 | |
| Endothelin-1 | 1.12 | 0.50–2.48 | 0.78 | |
| Galectin-3 | 1.61 | 0.84–3.10 | 0.15 | |
| Insulin | 0.98 | 0.43–2.24 | 0.96 | |
| Total cholesterol | 1.51 | 0.79–2.89 | 0.21 | |
| Leptin | 1.04 | 0.46–2.35 | 0.92 | |
| Group 1 versus group 5 | cTnI | 3.44 | 1.71–6.93 | 0.00 |
| ANGPTL3 | 0.16 | 0.05–0.55 | 0.00 | |
| NOx | 1.79 | 0.96–3.35 | 0.07 | |
| CRP | 2.24 | 1.23–4.10 | 0.01 | |
| PCSK9 | 0.89 | 0.47–1.65 | 0.70 | |
| Endothelin-1 | 0.65 | 0.30–1.42 | 0.28 | |
| Galectin3 | 1.62 | 0.86–3.06 | 0.13 | |
| Insulin | 1.00 | 0.47–2.12 | 1.00 | |
| Total cholesterol | 1.35 | 0.72–2.56 | 0.35 | |
| Leptin | 1.28 | 0.59–2.76 | 0.53 | |
| Group 1 versus group 6 | cTnI | 3.47 | 1.77–6.81 | 0.00 |
| ANGPTL3 | 0.10 | 0.03–0.33 | 0.00 | |
| NOx | 1.50 | 0.83–2.71 | 0.18 | |
| CRP | 2.27 | 1.25–4.14 | 0.01 | |
| PCSK9 | 0.88 | 0.48–1.64 | 0.69 | |
| Endothelin-1 | 0.42 | 0.20–0.91 | 0.03 | |
| Galectin3 | 1.56 | 0.86–2.85 | 0.15 | |
| Insulin | 0.93 | 0.46–1.88 | 0.83 | |
| Total cholesterol | 1.29 | 0.68–2.42 | 0.44 | |
| Leptin | 1.28 | 0.62–2.65 | 0.51 | |
| Nonfatal AMI | ||||
| Group 3 versus group 4 | cTnI | 1.97 | 1.11–3.50 | 0.02 |
| ANGPTL3 | 0.92 | 0.52–1.63 | 0.78 | |
| NOx | 3.05 | 1.75–5.30 | 0.00 | |
| CRP | 1.12 | 0.63–2.00 | 0.69 | |
| PCSK9 | 1.72 | 0.98–3.02 | 0.06 | |
| Endothelin-1 | 0.84 | 0.46–1.54 | 0.58 | |
| Galectin3 | 0.94 | 0.53–1.66 | 0.83 | |
| Insulin | 1.46 | 0.83–2.54 | 0.19 | |
| Total cholesterol | 1.44 | 0.83–2.47 | 0.19 | |
| Leptin | 0.88 | 0.48–1.63 | 0.69 | |
| Group 3 versus group 5 | cTnI | 1.84 | 1.02–3.33 | 0.04 |
| ANGPTL3 | 1.89 | 1.08–3.28 | 0.02 | |
| NOx | 2.76 | 1.61–4.73 | 0.00 | |
| CRP | 1.06 | 0.57–1.97 | 0.84 | |
| PCSK9 | 1.21 | 0.70–2.10 | 0.49 | |
| Endothelin | 1.30 | 0.70–2.40 | 0.40 | |
| Galectin-3 | 1.02 | 0.57–1.81 | 0.94 | |
| Insulin | 1.41 | 0.78–2.54 | 0.26 | |
| Total cholesterol | 1.59 | 0.92–2.73 | 0.09 | |
| Leptin | 0.71 | 0.39–1.28 | 0.25 | |
Significant values are in [italics].
PCSK9, proprotein convertase subtilisin/kexin type; ANGPTL3, angiopoietin-like protein 3; NOx, nitrate and nitrite; cTnI, cardiac troponin I; CRP, C-reactive protein; eHR, estimated hazard ratio.