Table 1:
MDD and Healthy Volunteer Participant Characteristics
| MDD (n=60) | HV (n=31) | p-value | |
|---|---|---|---|
| Age (yrs.) | 39.2 ± 11.2 | 31.7 ± 10.4 | p=0.003 |
| % Female | 53.3% | 51.6% | p=1 |
| % Hispanic | 20.0% | 9.7% | p=0.26 |
| % Race | 75.0% White 6.7% Asian 11.7% Black 5.0% More than one race 1.7% American Indian/Alaskan Native |
48.4% White 19.4% Asian 19.4% Black 3.2% More than one race 9.7% unknown/not reported |
p=0.02 |
| Years Education | 15.6 ± 2.6 | 16.1 ± 1.9 | p=0.27 |
| BDI | 22.6 ± 9.9 | 1.4 ± 2.1 | p<0.001 |
| HDRS-17 | 18.1 ± 4.4 | 1.2 ± 2.0 | p<0.001 |
| SSI Total Score | 5.3 ± 6.7 | 0 ± 0 | p<0.001 |
| % Suicide Attempt History* | 31.7% | 0% | p<0.001 |
| [11C]DASB Injected Dose (mCi) | 16.2 ± 2.3 | 16.1 ± 2.4 | p=0.92 |
| Lifetime Axis I Disorders | - | - | |
| At least one comorbid Axis I disorder | 67.8% | - | - |
| Generalized anxiety disorder | 6.8% | - | - |
| Post-traumatic stress disorder | 18.6% | - | - |
| Obsessive compulsive disorder | 8.5% | - | - |
| Attention-deficit hyperactive disorder | 5.08% | - | - |
| Panic disorder | 10.2% | - | - |
| Social phobia | 16.9% | - | - |
| At least one lifetime substance use disorder | 15.3% | - | - |