Fig. 3.

Effects of GYY4137 and HMPSNE on MTT conversion and LDH release, indices of mitochondrial activity and cell viability. A Analysis of MTT conversion ability in GYY4137-treated (1, 3, and 6 mM) and B HMPSNE-treated (30, 100 µM) cells after differentiation (day 7). C LDH assay in GYY4137 and D HMPSNE-treated cells after differentiation (day 7). Data refer to mean values of N = 5 independent experiments ± SEM. *p < 0.05 and **p < 0.01 show significant effects of GYY4137 or HMPSNE on MTT or LDH values compared to control values in the absence of pharmacological modulator treatment