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. 2022 Mar 5;44(4):1941–1960. doi: 10.1007/s11357-022-00536-0

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© The Author(s) 2022, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic characterization of HgSM macrophages. A qRT-PCR analysis of NF-kB, Il-1a, TGF-b, PPAR-g, and CD163 expression in macrophages. B qRT-PCR analysis of TNF-α, IL-8, IL-6, IL-1β, and IL-10 expression in macrophages. C IL-1β and IL-6 concentration (pg/ml) measured by ELISA in the cell culture supernatants. D Representative immunoblot and quantification of IL-1β expression in M0, M1, M2, and HgSM macrophages. Data are expressed as mean ± SD, *p≤0.05; **p≤0.01; ***p≤0.001; ^§p≤0.05; ^§§p≤0.01; ^§§§p≤0.001. *vs M0, ^§vs M1