Fig. 2.

mda RNAi is sufficient to rescue the hyperuricemia model’s decreased lifespan phenotype. a Lifespan rescue of whole-body mda RNAi (BL33362) crossed with hyperuricemia model (Da-GS, uro RNAi, TRiP empty vector control strain BL36303; number of flies from top of legend to bottom, n = 1264, 1334, 561, and 585). b Breakdown of mda RNAi (BL33362) lifespan effects in hyperuricemia model background (shaded red) or tissue-specific inhibition in wild-type backgrounds (shaded gray). AL − / + indicates flies fed ethanol or RU486, respectively. All p values from coxph() function in survival package in R (survival curves and cox proportional hazards results can be found in Sup Figs. 2 and 3, and Table S2, respectively)