Table 1.
Ongoing Proton and Carbon Ion Radiotherapy Clinical Trials in GBM
| Clinical status | NCT Number | Study | Initiated | Completion date/Estimated |
|---|---|---|---|---|
| Phase III | NCT04536649 | Proton and carbon ion beam radiation vs photon beam radiation for newly diagnosed GBM | 2020 | 2023 |
| Phase II (CLEOPATRA) | NCT01165671 | Carbon ion boost applied, after combined radiochemotherapy with TMZ vs a proton boost, after radiochemotherapy with TMZ in patients with primary GBM | 2010 | completed |
| Phase II | NCT01854554 | IMPT vs IMRT in GBM | 2013 | completed |
| Phase III (GRIPS) | NCT04752280 | IMRT vs proton radiotherapy in GBM | 2021 | 2027 |
| Phase II | NCT02179086 | Hypofractionated dose-escalated photon IMRT or PBT vs standard photon irradiation with concomitant and adjuvant TMZ in patients with newly diagnosed GBM | 2014 | |
| Phase II | NCT03778294 | 18F-DOPA-PET/MRI scan in imaging elderly patients with newly diagnosed grade iv malignant glioma or GBM during planning for a short course of proton beam radiation therapy | 2019 | |
| Pilot study | NCT03587038 | OKN-007 in combination with adjuvant TMZ chemoradiotherapy for newly diagnosed GBM | 2018 | 2025 |
| Open Label | NCT0528463 | Spectroscopic MRI, proton therapy, and Avastin for glioblastoma patients | 2022 |
Abbreviations: GBM, glioblastoma; TMZ, temozolomide; IMPT, Intensity-modulated proton radiotherapy; IMRT, Intensity-modulated radiotherapy; MRI, Magnetic resonance imaging.