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. 2022 Oct 29;20:494. doi: 10.1186/s12967-022-03713-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — The screening of unique TCR patterns in gliomas compared to normal tissues. A The clustering of TCR clonotypes into patterns with GLIPH2 and analysis of patterns with edgeR. B The top 10 predicted TCR clonotype-neoantigen pairs by DLpTCR. C Total reads of three patterns in prevaccination and postvaccination cells in four patients. D Reads of three patterns in prevaccination and postvaccination cells in every patient. E The significant expanded TCR clonotypes after vaccination. F The top 10 predicted TCR clonotype-neoantigen pairs by DLpTCR with the expanded TCR clonotypes