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. 2022 Oct 29;22:330. doi: 10.1186/s12935-022-02746-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — BMSCs derived exosomes increased the level of XIST in osteosarcoma cells. A The exosomes from BMSCs analyzed by TEM; B The levels of exosome markers CD9, CD63, CD81 and endoplasmic reticulum marker calnexin detected by western blot (n = 3); C PKH26-labeled exosomes internalized by osteosarcoma cellline MG63 and 143B; D qRT-PCR analysis of the level of XIST in osteosarcoma cell lines MG63 and 143B treated with different concentrations of exosomes from BMSCs (n = 3); E FISH results to observe the level and localization of XIST in osteosarcoma cell lines MG63 and 143B after treatment with BMSCs derived exosomes. ** represents p < 0.01