Fig. 6.

BMSCs derived exosomal XIST regulated ACLY expression in osteosarcoma cells by binding miR-655. A Western blot analysis the effect of BMSCs derived exosomal XIST combined with miR-655 on the expression of ARPP19, TOB1 and ACLY in osteosarcoma cells (n = 3); B At animal level, western blot analysis the effect of BMSCs derived exosomal XIST combined with miR-655 on ACLY expression (n = 3); C The binding pattern of miR-655 and the ACLY 3'-UTR and the corresponding mutation information; D The binding of miR-655 and the ACLY 3'-UTR and their possible sites analyzed by dual luciferase reporter gene assay (n = 3). ** represents p < 0.01