Table 7.

Comparison of Central to Peripheral LC Zone Structural Parameters in Control and Glaucoma

		Percent Difference Peripheral Over Central (%)
Tissue Component	Structural Parameter	Control	P	Glaucoma	P
GFAP in pores	Area fraction, GFAP area/mask area	4.9	0.0008*	4.2	0.011*
	Average process width, µm	2.9	0.005*	2.3	0.029*
F-actin in pores	Area fraction, F-actin area/mask area	1.1	0.402	3.4	0.044*
	Average process width, µm	3.9	2.34E-08*	2.1	0.001*
Beams (SHG)	Mean area of pores, µm2	−18.2	0.022*	−5.4	0.415
Nuclei overall	Count × 103/mask area, n/µm2	−23.6	0.251	−5.4	0.012*
Nuclei in pores	Count × 103/mask area, n/µm2	10.3	0.059	−8.5	0.041*
	Area percentage of nuclei in pores	21.5	0.007*	6.6	0.092
Nuclei on beams	Count × 103/mask area, n/µm2	−14.2	0.007*	−4.6	0.133
Axon compartments	Number of axonal compartments	−19.0	1.34E-09*	−11.5	3.11E-05*

^*Indicates significant P values from multivariable linear mixed-effect models.