Table 2.

Mitochondria-associated therapeutic strategies against COVID-19

Potential molecules	Mode of action	References
Melatonin	Address mitochondrial redox imbalance	[123]
Mitoquinol	Antioxidants managing mtROS	[91]
Mito-TEMPO	Scavenge mitochondrial superoxide and reduce mtROS	[29, 91, 130, 131]
Mito-MES	mitochondrial antioxidant	[130]
N-acetyl cysteine	Antioxidants used in restoration of mitochondrial function	[91]
2-DG	Glycolysis inhibition	[74, 126]
Limonoids, triterpenoids	Block nsp 13	[127]
Spautin 1	Inhibit USP 13 to deubiquitinate nsp 13	[109]
Ruthenium red	Mitochondrial calcium uniporter inhibitor to fix calcium imbalance	[129]