Figure 9.

EP300/PCAF: a master regulator of activity-regulated NSPs and a possible link to long-term cellular changes via chromatin remodeling. The Ingenuity Causal Network Analysis identified the EP300/PCAF complex as the top master regulator predicted to control intermediate regulators that are responsible for protein expression changes observed in our NSP dataset. The figure shown here is a schematic of the molecular interaction network superimposed on cellular compartments, the nucleus, cytoplasm, plasma membrane, and extracellular space. TP53 (p53), EP300, and KAT2b are prominent nodes that interact with EP300/PCAF and that receive and distribute signals from a dispersed network of proteins located in the different subcellular compartments. For molecular relationships, solid lines represent direct interactions and broken lines represent indirect interactions. The arrows represent activation of targets and blocked lines represent inhibition of the targets. The orange and blue lines indicate that the relationship leads to activation or inhibition, respectively. The yellow lines indicate that the findings are inconsistent with the state of downstream molecule. The shapes and colors of the symbols indicate protein class and expression levels, respectively, as detailed in Extended Data Figure 9-4 (Extended Data Figs. 9-1, 9-2, 9-3, see for details).