Figure 3.

Neocortical and hippocampal ripple characteristics in NREM and waking. A-E, NREM and waking cortical ripple density (A), peak 70-100 Hz analytic amplitude (B), oscillation frequency (C), duration (D), and percent change in mean >200 Hz analytic amplitude during ripples compared with a −2 to −1 s baseline (E). Distributions are comprised of channel means (SEEG Patients S1-S17; N = 273 neocortical channels, N = 28 hippocampal channels). Circles represent medians. Horizontal lines indicate means. Vertical lines indicate interquartile ranges. FDR-corrected p values, linear mixed-effects models with post hoc analyses, patient as random effect. ns, Nonsignificant factor precluding post hoc analysis. For distributions across individual ripples, see Figure 4. For distributions across individual patients, see Figure 5. Figure 1B, C shows that the ∼90 Hz ripple frequency we measured is not because of filtering including the detection bandpass.