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. Author manuscript; available in PMC: 2022 Oct 29.
Published in final edited form as: J Med Chem. 2021 Oct 12;64(20):15313–15333. doi: 10.1021/acs.jmedchem.1c01353

Scheme 1.

Scheme 1.

Reagents and conditions: a) K2CO3/acetonitrile, reflux, 12 h; b) NaHCO3/DMF, RT, 3–4 h; c) K2CO3/DMF, RT, 3–4 h; d) NaI, K2CO3/acetone, reflux, 8 h; e) K2CO3/DMF, RT, 3–4 h; f) 1230, NaHCO3/acetonitrile, reflux, 12 h; g) 14,23 NaBH(OAc)3/DCE/AcOH, RT, 5 h.