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. Author manuscript; available in PMC: 2022 Oct 29.
Published in final edited form as: J Med Chem. 2019 Nov 14;63(5):2343–2357. doi: 10.1021/acs.jmedchem.9b01188

Scheme 1.

Scheme 1.

Synthesis of compounds 8a-g and 9a-e.a

aReagents and conditions: (a) appropriate oxirane, isopropanol, reflux, overnight; (b) appropriate halide, K2CO3, acetonitrile, reflux; (c) CDI, 3-phenylpropanoic acid, THF, RT, overnight; (d) H2O2, CH3COOH/CH3OH, 40 °C, overnight.