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. Author manuscript; available in PMC: 2022 Oct 29.
Published in final edited form as: J Med Chem. 2019 Nov 14;63(5):2343–2357. doi: 10.1021/acs.jmedchem.9b01188

Scheme 4.

Scheme 4.

Synthesis of diazaspiro analoguesa

aReagents and conditions: (a) tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate, K2CO3, acetonitrile, reflux, overnight; (b) TFA, DCM, RT, 5 h; (c) appropriate oxirane, isopropyl alcohol, reflux, 18–48 h; (d) H2O2, CH3COOH/CH3OH, RT, 48 h.