Table 1.

Binding Data for Sulfenyl-, and Sulfinylalkylamine Analogues.^a

^aEach K_i value represents data from at least three independent experiments, each performed in triplicate. K_i values were analyzed by PRISM. Binding assay procedures are described in detail in Experimental Methods.

^bConcentration (log) response curves were fitted to a logistic equation (three parameters assuming complete block of the current at very high test compound concentrations) to generate estimates of the 50% inhibitory concentration (IC₅₀). The concentration-response relationship of each compound was constructed from the percentage reductions of current amplitude by sequential concentrations. NT; not tested.

^cdata from ref. 32.

^ddata from ref. 62.