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. 2022 Oct 29;221:112986. doi: 10.1016/j.colsurfb.2022.112986

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Fig. 7 — Binding RBD affinities for optimized mAbs obtained through the three cycles electrostatic optimization pipelines. (a) Left panel: mAb P01’’’ based on the Rosetta-designed P01. (b) Right panel: mAb P06’’’ based on the Rosetta-designed P06. Data from the estimated βw_min values for the molecular complexation between RBDs from different variants with P01’’’ (P01 with three mutations L: R18E and H: K20E and K84A) and P06’’' (P06 with three mutations H: K20A, G61E, and K84A), respectively, are shown in blue bars. Data for the complexes with the original Rosetta-designed mAbs (RBD_wt-P01 and RBD_wt-P06) before the electrostatic optimization process and CR3022 ´ (RBD_wt-CR3022 ´) are given in the purple and red bars, respectively, for comparison. The purple lines are drawn to guide the eyes for the comparison with the outcomes for the RBD_wt. See the text for more details.