Table 2:
Variable | Hazard ratio for 60-day survival (95% confidence interval) | P | Hazard ratio for overall survival (95% confidence interval) | P |
---|---|---|---|---|
Patient characteristics at ICU entry | ||||
Age (above vs. below median) | 0.83 (0.25, 2.71) | 0.75 | 0.89 (0.42, 1.89) | 0.76 |
CD4 count (<100 vs. ≥100) | 1.35 (0.41, 4.42) | 0.62 | 0.77 (0.34, 1.72) | 0.52 |
HIV VL (<25 vs. ≥25) | 0.37 (0.10, 1.39) | 0.14 | 1.00 (0.47, 2.15) | 0.99 |
SOFA score (<6 vs. ≥6) | 1.73 (0.51, 5.91) | 0.38 | 1.43 (0.66, 3.09) | 0.37 |
KSHV VL (above vs. below median) | 1.82 (0.48, 6.89) | 0.37 | 1.44 (0.66, 3.16) | 0.37 |
KAD diagnoses at ICU discharge or death | ||||
MCD +/− KS | 0.28 (0.04, 2.15) | 0.21 | 0.59 (0.22, 1.57) | 0.29 |
KICS +/− KS | 0.82 (0.22, 3.09) | 0.77 | 1.35 (0.59, 3.08) | 0.47 |
PEL +/− MCD +/− KS | 3.37 (0.99, 11.55) | 0.05 | 2.03 (0.95, 4.35) | 0.07 |
ICU Interventions | ||||
Vasopressors | 3.25 (0.86, 12.25) | 0.08 | 2.23 (1.02, 4.88) | 0.05 |
Mechanical ventilation | 4.95 (1.44, 16.96) | 0.01 | 2.99 (1.29, 6.97) | 0.01 |
Chemotherapy or other for KAD | 3.22 (0.85, 12.14) | 0.85 | 1.54 (0.71, 3.32) | 0.27 |
Cytokines at admission to ICU – (above vs. below median) | ||||
Interferon-γ, pg/mL | 1.29 (0.34, 4.85) | 0.71 | 1.65 (0.68, 4.02) | 0.27 |
IL-10, pg/mL | 1.33 (0.35, 5.03) | 0.67 | 1.14 (0.51, 2.56) | 0.75 |
IL-12, pg/mL | 0.82 (0.24, 2.82) | 0.76 | 1.06 (0.47, 2.37) | 0.90 |
IL-13, pg/mL | 0.40 (0.12, 1.32) | 0.13 | 0.67 (0.31, 1.43) | 0.30 |
IL-1β, pg/mL | 0.65 (0.20, 2.12) | 0.47 | 0.77 (0.36, 1.71) | 0.54 |
IL-2, pg/mL* | 1 (NA) | NA | 1 (NA) | NA |
IL-4, pg/mL | 1.30 (0.35, 4.91) | 0.70 | 1.43 (0.62, 3.28) | 0.40 |
IL-6, pg/mL | 1.33 (0.35, 5.03) | 0.67 | 1.79 (0.76, 4.22) | 0.19 |
IL-8, pg/mL | 0.71 (0.21, 2.41) | 0.58 | 0.54 (0.25, 1.15) | 0.11 |
TNF-α, pg/mL | 0.74 (0.22, 2.53) | 0.63 | 0.84 (0.38, 1.85) | 0.66 |
No values below median