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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Trends Mol Med. 2022 Sep 15;28(11):979–988. doi: 10.1016/j.molmed.2022.08.010

Figure 1: Role of class-switching in antibody maturation and neutralization breadth.

Figure 1:

Schematic representation of the role of CSR in antibody maturation to acquire improved neutralization. (A) The traditional arms race involving increasing SHM which enables the neutralization of new viral variants and neutralization breadth. (B) CSR involving subtypes with reduced activity against circulating viral variants resulting in the termination of that sub-lineage (C) CSR involving favourable subtypes which can either restore a previous detrimental switch termed “switch redemption” or have enhanced activity compared to a previous subtype.