Skip to main content
. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Trends Mol Med. 2022 Sep 15;28(11):979–988. doi: 10.1016/j.molmed.2022.08.010

Figure 2: Key features of IgG3 and IgA1 antibodies that mediate improved neutralization breadth and potency.

Figure 2:

(A) Schematic of IgG1, IgG3, and IgA1 antibodies showing different antibody regions including the heavy and light chain variable regions (VH and VL), the three heavy chain constant regions (CH1 - CH3), the light chain constant region (CL), and the hinge region that make up the Fab and Fc portions. Highlighted in green and purple are the key features for IgG3 and IgA1 that mediate improved neutralization, respectively. (B) Mechanisms through which IgG3 mediates increased neutralization breadth, potency, and ADCP compared to IgG1. (C) The potential mechanisms through which IgA improves neutralization breadth and potency compared to IgG1.