Table 2.
End-of-study levels of different biomarkers in the LoDoCo2 subpopulation
| Biomarker | Colchicine [n = 895] | Placebo [n = 881] | p value | ULN |
|---|---|---|---|---|
| Renal function | ||||
| Creatinine [µmol/L] | 82.7 (74.0–94.4) | 82.6 (73.5–94.0) | 0.99 | 110 |
| Blood urea nitrogen [mmol/L] | 6.3 (5.3–7.5) | 6.3 (5.3–7.5) | 0.96 | 30 |
| Estimated glomerular filtration rate [mL/min/1.73 m2] | 79.3 (15.3) | 79.6 (15.4) | 0.76 | 120 |
| Liver function | ||||
| Alanine aminotransferase [U/L] | 30.0 (22.0–40.0) | 26.0 (19.0–34.0) | < 0.01 | 40 |
| γ-Glutamyl transferase [U/L] | 30.0 (21.0–48.0) | 30.0 (21.0–44.0) | 0.31 | 60 |
| Bilirubin [µmol/L] | 9.5 (7.0–12.2) | 9.2 (7.2–12.0) | 0.73 | 20 |
| Albumin [g/L] | 43.0 (2.4) | 42.6 (2.5) | < 0.01 | 50 |
| Creatine kinase | ||||
| Creatine kinase [U/L] | 123.0 (84.0–184.0) | 110.0 (77.0–164.0) | < 0.01 | 190 |
Data are expressed as mean (SD) or median (25th–75th percentile). p values were calculated using an independent samples t test or Mann–Whitney U test where applicable
SD standard deviation, ULN upper limit of normal, U unit, LoDoCo2 Low-Dose Colchicine-2 trial