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. 2022 Oct 29;13:6463. doi: 10.1038/s41467-022-34112-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Differences in polygenic risk score (PRS) for ASD and BMI between participants and their respective mid-parent score. Box plots depict the median and quartiles of polygenic transmission disequilibrium test (pTDT) deviation, and the minima and maxima of box plots indicate 3× the interquartile range-deviated pTDT deviations from the median. Dots represent pTDT deviations of participants. P values for each subgroup indicate the probability that the mean of the pTDT deviation distribution is not greater than zero (one-sided Welch’s t-test was performed assuming pTDT deviation to be greater than zero), as depicted by the dotted line. Source data are provided as a Source Data file.