Skip to main content
. 2022 Aug 8;11(5):1901–1916. doi: 10.1007/s40121-022-00680-2

Table 2.

Characteristics of HBsAg-negative and HBcAb-positive US adults, NHANES, 2001–2018 (weighted)

Characteristics NHANES 2001–18
(Total)
NHANES 2001–2006
(Era 1)
NHANES 2007–2012
(Era 2)
NHANES 2013–2018
(Era 3)
Weighted number, in millions (95% CI) 9.87 (9.24–10.50) 10.75 (9.70–11.80) 8.97 (7.94–10.01) 9.90 (8.82–11.08)
Sex, % female (95% CI) 44.31 (41.79–46.83) 43.44 (39.00–47.87) 48.27 (44.02–52.51) 41.67 (37.13–46.21)
Age, years, mean (95% CI) 53.67 (52.98–54.36) 51.60 (50.34–52.86) 53.18 (52.06–54.30) 56.37 (55.24–57.50)
BMI, kg/m2, mean (95% CI) 27.75 (27.40–28.10) 27.17 (26.66–27.68) 28.05 (27.32–28.78) 28.29 (27.68–28.90)
Ethnicity, % (95% CI)
 Non-Hispanic white 40.30 (37.15–43.44) 46.24 (41.74–50.74) 35.29 (29.10–41.48) 38.38 (32.19–44.56)
 Non-Hispanic black 25.07 (22.75–27.40) 25.36 (21.30–29.41) 25.70 (21.95–29.46) 24.20 (19.81–28.59)
 Others 34.62 (31.79–37.44) 28.39 (23.76–33.02) 39.00 (33.42–44.57) 37.41 (32.55–42.27)
Education, % (95% CI)
 Less than high school 26.57 (24.40–28.73) 27.76 (24.88–30.65) 26.25 (22.38–30.12) 25.56 (20.98–30.13)
 High school or above 73.42 (71.26–75.59) 72.23 (69.34–75.11) 73.74 (69.87–77.61) 74.43 (69.86–79.01)
Income-to-poverty ratio level, % (95% CI)
 0–1.0 21.50 (19.26–23.74) 18.37 (15.37–21.37) 22.12 (18.66–25.58) 24.46 (19.23–29.70)
 > 1.0 78.49 (76.25–80.73) 81.62 (78.62–84.62) 77.87 (74.41–81.33) 75.53 (70.29–80.76)
Alcohol drinking, % (95% CI)
 Non-drinker 28.33 (26.03–30.62) 30.10 (26.05–34.16) 29.98 (25.46–34.49) 25.06 (21.57–28.54)
 Drinker 71.66 (69.37–73.96) 69.89 (65.83–73.94) 70.05 (65.50–74.59) 74.93 (71.45–78.42)
Excessive alcohol drinkinga
 Non-drinker 31.60 (29.13–34.07) 30.10 (26.05–34.16) 29.98 (25.43–34.52) 35.45 (31.45–40.27)
 Low to moderate drinker 58.67 (56.13–61.21) 59.40 (54.82–63.97) 60.23 (56.61–63.85) 50.56 (50.56–60.79)
 Heavy drinker 9.71 (8.16–11.26) 10.49 (8.49–12.48) 9.78 (6.48–13.09) 8.45 (5.40–11.51)
Smoking status, % (95% CI)
 Never smoker 47.69 (45.25–50.13) 42.02 (38.20–45.83) 50.81 (46.14–55.48) 51.01 (46.58–55.44)
 Former smoker 25.15 (23.36–26.95) 24.69 (21.43–27.95) 24.87 (21.62–28.11) 25.9 (22.99–28.84)
 Current smoker 27.14 (24.62–19.66) 33.28 (29.03–37.52) 24.31 (19.89–28.73) 23.06 (18.65–27.46)
Liver disease, % (95% CI) 12.05 (10.26–13.84) 11.28 (8.19–14.36) 12.11 (8.69–15.53) 12.84 (9.86–15.81)
Chronic hepatitis C,b % (95% CI) 9.56 (7.96–11.17) 15.51 (12.05–18.97) 7.92 (5.07–10.78) 15.51 (12.05–18.97)
Diabetes, % (95% CI) 12.22 (10.94–13.49) 10.78 (8.38–13.17) 12.52 (10.11–14.93) 13.51 (11.56–15.45)
Hypertension, % (95% CI) 30.86 (28.74–32.97) 25.76 (22.60–28.93) 29.55 (25.69–33.41) 37.57 (33.34–41.80)
HBsAb-negative, % (95% CI) 21.48 (19.56–23.41) 18.52 (15.47–21.57) 23.34 (20.24–26.45) 23.02 (19.01–27.03)
AST, U/L, mean (95% CI) 28.08 (27.14–29.02) 28.15 (26.71–29.58) 30.33 (28.29–32.37) 25.96 (24.43–27.48)
ALT, U/L, mean (95% CI) 27.52 (26.55–28.49) 28.66 (26.68–30.64) 28.77 (27.25–30.28) 25.16 (23.65–26.66)
Platelets, × 103/μL, mean (95% CI) 243.90 (240.35–247.44) 261.45 (255.06–267.84) 236.84 (230.39–243.30) 231.22 (225.95–236.50)
FIB-4 score, mean (95% CI) 1.37 (1.31–1.43) 1.23 (1.13–1.34) 1.47 (1.33–1.61) 1.43 (1.36–1.50)

Participants had complete laboratory values for calculating FIB-4 scores (age ≥ 20)

All estimates accounted for complex survey designs and sampling weights of NHANES

aLow to moderate drinker defined as drinking < 1 drink/day in women and < 2 drinks/day in men, and heavy drinker defined as ≥ 1 drink/day in women and ≥ 2 drinks/day in men

bChronic hepatitis C is defined as hepatitis C virus RNA positive