Table 2.
MIC range, MIC50, and MIC90 of cefoperazone alone and in combination with sulbactam (1:1) against E. coli isolates
| E. coli (n = 247) | MIC (mg/L) | Susceptibility [% (n)]a | ||||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Range | S | I | R | |
| CPZ | 1 | > 64 | < 0.0625 to > 64 | 64.8% (160) | 3.2% (8) | 32.0% (79) |
| CPZ/SUL | 1 | 8 | < 0.0625 to > 64 | 99.2% (245) | 0% (0) | 0.8% (2) |
| CPZnS E. coli (n = 87) | MIC (mg/L) | Susceptibility [% (n)]a | ||||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Range | S | I | R | |
| CPZ | > 64 | > 64 | 32 to > 64 | 0% (0) | 9.2% (8) | 90.8% (79) |
| CPZ/SUL | 4 | 16 | 2 to > 64 | 97.7% (85) | 0% (0) | 2.3% (2) |
CPZnS cefoperazone-non-susceptible, CPZ cefoperazone, SUL sulbactam, CPZ/SUL cefoperazone/sulbactam
aCLSI 2019 breakpoints of cefoperzaone for Enterobacterales: S, MIC ≤ 16 mg/L; I, MIC = 32 mg/L; R, MIC ≥ 64 mg/L