Table 1.
Characteristics of patients receiving CAZ/AVI-based and PMB-based therapeutic regimens
| Variable | CAZ/AVI (n = 82) | PMB (n = 82) | P value |
|---|---|---|---|
| Age, years | 63.2 ± 17.0 | 67.5 ± 12.3 | 0.173 |
| Sex (female) | 56 (68.3) | 49 (59.8) | 0.255 |
| TBW, kg | 65.2 ± 13.8 | 64.1 ± 13.2 | 0.586 |
| Primary site of infection | |||
| Primary bloodstream infection | 10 (12.2) | 12 (14.6) | 0.647 |
| Respiratory infection | 38 (46.3) | 54 (65.9) | 0.012 |
| Abdominal infection | 17 (20.7) | 12 (14.6) | 0.306 |
| Urinary tract infection | 12 (14.6) | 3 (3.7) | 0.027 |
| Other infections | 5 (6.1) | 1 (1.2) | 0.210 |
| Sepsis | 41 (50) | 18 (22.0) | < 0.001 |
| Polymicrobial infection | 16 (19.5) | 9 (11.0) | 0.128 |
| APACHE II score (antimicrobial treatment onset) | 16.5 (14–19) | 16.5 (14–19) | 0.895 |
| CrCl, mL/min | 76.7 (46.4–119.8) | 56.8 (39.0–95.1) | 0.039 |
| CRRT | 11 (13.4) | 21 (25.6) | 0.049 |
| ECMO | 1 (1.2) | 1 (1.2) | 1.000 |
| Length of ICU stay before starting antimicrobial therapy, days | 23 (11.8–53.3) | 35.5 (21.5–54.8) | 0.017 |
| Vasoactive drugs | 46 (56.1) | 42 (51.2) | 0.531 |
| Mechanical ventilation | 54 (65.9) | 51 (62.2) | 0.625 |
| Comorbidities | |||
| Cardiovascular disease | 28 (34.1) | 56 (68.3) | < 0.001 |
| Respiratory disease | 38 (46.3) | 36 (43.9) | 0.754 |
| Central nervous system disease | 17 (20.7) | 21 (25.6) | 0.459 |
| Autoimmune disease | 9 (11.0) | 6 (7.3) | 0.416 |
| Liver disease | 25 (30.5) | 19 (23.2) | 0.290 |
| Renal insufficiency | 22 (26.8) | 30 (36.6) | 0.179 |
| Diabetes | 18 (22.0) | 21 (25.6) | 0.582 |
| Organ transplantation | 10 (12.2) | 5 (6.1) | 0.176 |
| Neoplasia | 25 (30.5) | 10 (12.2) | 0.004 |
| CCI score | 4 (3–6) | 5 (3.8–6) | 0.223 |
| Antimicrobial treatment duration, days | 14 (10–14) | 9 (6–14.3) | 0.001 |
| Antimicrobial combination therapy | 49 (59.8) | 60 (73.2) | 0.069 |
All data are exhibited as number (%), mean ± standard deviation (SD), or median (interquartile range)