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. 2022 Oct 18;119(43):e2205417119. doi: 10.1073/pnas.2205417119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — APCs in the dLNs and CNS show a reduction in MHCII Ag presentation and inflammatory gene signature following dMP MOG treatment in mice with advanced EAE. Dot plots highlight Ag presentation, proinflammatory, cell cycle, and migration genes differentially expressed in (A) cDC2s, (B) macrophages, (C) Ly6c^Hi monocytes, and (D) B cells in the dLNs on day 7. Dot plots highlighting Ag presentation, proinflammatory, cell cycle, and migration genes differentially expressed in (E) microglia, (F) MHC II^High cells, (G) Ly6c^Hi monocytes, and (H) B cells in the spinal cord on day 7. Of note are Ag presentation, proinflammatory, anti-inflammatory, cell cycle, and migration genes. Genes with a p_adjusted of <0.1 were considered significant. n = 2 mice per group in the dLNs and n = 1 mouse per group in the CNS.