Fig. 7.
T cells in dLNs and CNS show a reduction in inflammatory genes following dMP MOG treatment in mice with advanced EAE. (B) Dot plots highlighting genes of interest differentially expressed in (A) Th17 cells, (B) naive CD4+ T cells, (C) activated CD8+ T cells, and (D) naive CD8+ T cells in the dLNs on day 2, specifically TCR signaling, proinflammatory, cell cycle, and migration genes. Dot plots showing proinflammatory, activation, and cell cycle genes in (E) CD4+ T cells, (F) Treg cells, and (G) CD8+ T cells in the spinal cord on day 7. Genes with a padjusted of <0.1 were considered significant. n = 2 mice per group in the dLNs and n = 1 mouse per group in the CNS.