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. 2022 Oct 17;119(43):e2210421119. doi: 10.1073/pnas.2210421119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 3. — Netrin-G1 is expressed in developing and adult Aβ RA-LTMRs and Aδ-LTMRs. (A–D) Immunohistochemistry (IHC) images of T11–T13 DRG sections from wild-type and Ntng1^−/− animals (n = 3 animals per genotype) at P40, showing expression of Netrin-G1 in NFH⁺ DRG neurons (A), lanceolate and circumferential endings around hair follicles (B), Aβ RA-LTMRs innervating Meissner corpuscles (C), and lumbar (L4) spinal cord (D). Netrin-G1 signal (green) is absent in Ntng1^−/− animals. IB4 labels a large subset of nonpeptidergic sensory neurons and S100 labels TSCs. (E and F) Thoracic DRG and back hairy skin sections obtained from P3 Ret^CreER; Ai14 animals (n = 3 animals) and TrkB^CreER; Ai14 animals (n = 3 animals) were stained with Netrin-G1 and Tomato to visualize Aβ RA-LTMRs and Aδ-LTMRs. NFH (blue) labels lanceolate endings of Aβ RA-LTMRs. a, apical; b, basal.