Figure 5.

Early functional aberrations in mitochondria before the onset of photoreceptor degeneration in rd1 retina. (A) Traces of mitochondrial OCR in retinal punches isolated from WT and rd1 mice at various ages from P3 to P14 (n = 12–29 retinal punches, for each group). BAM15 and rotenone were added at indicated time during experiments. Data are represented as mean ± SEM. (B) Basal mitochondrial OCR in WT and rd1 retinal punches at each age tested. Values were taken at 36 min, right before addition of BAM15. Plot of mitochondrial reserve capacity in WT and rd1 retinal punches at each age tested. Data are represented as mean ± SEM. Student t test, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.