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. 2022 Oct 29;22:455. doi: 10.1186/s12872-022-02882-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Visualization of the differential DNA methylation positions in aortic samples between Stanford-A acute aortic dissection and control group

(A) Principal component analysis showing the differences of DNA methylation between the two groups

(B) Percentages of differential DNA methylation in different genomic components

(C) Hypermethylation and hypomethylation in different genomic components

(D) Volcano plot presenting distribution and degree of the DNA methylation of the two groups. Red dots are the significantly hypermethylated positions and the blue dots are the significantly hypomethylated positions. The green dots are the positions with no significant difference. The top two significant hypermethylated and hypomethylated positions were labeled

(E) Heat map showing different features of DNA methylation profile between the two groups