Table 3.
Top 10 significant hypomethylated positions in Stanford-A AAD compared to healthy control
| CpG site | Gene | Chr | Gene region | Location | △Beta | P values |
|---|---|---|---|---|---|---|
| cg18264728 | DAB2 | chr5 | 5’UTR | N_Shelf | -0.528 | <0.001 |
| cg24753662 | TBX1 | chr22 | 5’UTR | Island | -0.519 | <0.001 |
| cg03551963 | -0.393 | <0.001 | ||||
| cg24531955 | LOXL2 | 3’UTR | -0.327 | <0.001 | ||
| cg04279411 | -0.320 | <0.001 | ||||
| cg18419977 | SLC22A18AS | chr11 | Body; TSS1500 | N_Shelf | -0.302 | <0.001 |
| cg20597486 | IFI16 | 5’UTR; 1stExon | -0.328 | <0.001 | ||
| cg15338782 | ATP10A | Body | -0.365 | <0.001 | ||
| cg00903308 | chr7 | N_Shore | -0.470 | <0.001 | ||
| cg01134144 | ARHGEF6 | TSS200 | -0.315 | <0.001 |
Abbreviations: 5’UTR, 5’-Untranslated region; 3’UTR, 3’-Untranslated region; TSS1500, 1500 bp upstream of transcription start site; TSS200, 200 bp upstream of transcription start site; N-Shelf, North shelf which are regions flanking island; N-Shore, North shore which are regions flanking island; Chr, Chromosome. AAD, Acute aortic dissection